On May 23, 2025, Professor Dong Zhifang's team from the Affiliated Children's Hospital of Chongqing Medical University published a research paper titled "Disruption of BAG3-mediated BACE1 Stabilization Alleviates Neuropathology and Memory Deficits in a Mouse Model of Alzheimer's Disease" in Science Advances.
Alzheimer's disease (AD) is the most common neurodegenerative disorder of the central nervous system, with complex pathogenesis and a lack of effective treatments.
The study found that BAG3 forms a ternary complex with HSP70 and BACE1, inhibiting the ubiquitin-proteasome degradation and autophagy-lysosome pathways of BACE1, thereby maintaining its stability and promoting Aβ production. Based on this discovery, the team successfully identified the specific binding site between BACE1 and BAG3 and developed a novel Tat-BACE1 polype
